An interesting line of investigation

I spent much of my childhood battling strep infections. I don't know if my OCD is related to this, but the idea that it could be is pretty intriguing. (I wasn't diagnosed as a child, though I had some symptoms then. I might check with my mom and see what she remembers.)

Childhood disorder prompts study of infection link to mental illness

Brody Kennedy was a typical sixth-grader who loved to hang out with friends in Castaic and play video games. A strep-throat infection in October caused him to miss a couple of days of school, but he was eager to rejoin his classmates, recalls his mother, Tracy.

Then, a week after Brody became ill, he awoke one morning to find his world was no longer safe. Paranoid about germs and obsessed with cleanliness, he refused to touch things and showered several times a day. His fear prevented him from attending school, and he insisted on wearing nothing but a sheet or demanding that his mother microwave his clothes or heat them in the dryer before dressing.

So began a horrific battle with a sudden-onset mental illness that was diagnosed as pediatric autoimmune neuropsychiatric disorder associated with streptococcus, or PANDAS. The puzzling name describes children who have obsessive-compulsive disorder that occurs suddenly — and often dramatically — within days or weeks of a simple infection, such as strep throat.

Here are a couple of other interesting articles about causes of abnormal psychophysiology:

Scans Show Brain Damage in Abused Teens

Adolescents reporting a history of abuse -- even nonphysical forms such as emotional neglect -- had deficits in gray-matter brain volume in numerous regions compared with other teens, researchers said.

Among 42 teens without psychiatric diagnoses, scores on the self-reported Childhood Trauma Questionnaire were inversely correlated with gray-matter volume in brain regions including the prefrontal cortex, striatum, amygdala, and cerebellum, as well as cortical regions associated with sensory function, according to Hilary P. Blumberg, MD, of Yale University, and colleagues.

Moreover, the specific patterns of gray-matter deficit measured via high resolution MRI varied according to the type of abuse participants reported, the researchers indicated in the December issue of Archives of Pediatric and Adolescent Medicine.

ADHD - Four Genes Linked To The Disorder

Four gene variants, all members of the glutamate receptor gene family, appear to be involved in vital brain signaling pathways in a sub-set of children with ADHD (attention deficit hyperactivity disorder), researchers from the Center for Applied Genomics at The Children's Hospital of Philadelphia reported in the journal Nature Genetics.